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selective mpc inhibitor uk5099  (Tocris)


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    Tocris selective mpc inhibitor uk5099
    MPC inhibition attenuates inflammatory response to palmitate plus LPS. (A–E) Primary hepatocytes transcript abundance of (A) Il1b , (B) Ccl2 , (C) Tnfa , and (D) Tgfb after 12hr treatment with 300 μM palmitate, LPS (0.01, 0.1, 1.0 ng/mL), and <t>UK5099</t> (5 μM) or vehicle control. (Hepatocytes were pooled from three mice in technical triplicate). (Data are presented as mean ± SEM; n = 3, *p < 0.05, **p < 0.01, ***p < 0.001).
    Selective Mpc Inhibitor Uk5099, supplied by Tocris, used in various techniques. Bioz Stars score: 95/100, based on 34 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/selective mpc inhibitor uk5099/product/Tocris
    Average 95 stars, based on 34 article reviews
    selective mpc inhibitor uk5099 - by Bioz Stars, 2026-06
    95/100 stars

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    1) Product Images from "The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity"

    Article Title: The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity

    Journal: Molecular Metabolism

    doi: 10.1016/j.molmet.2017.09.002

    MPC inhibition attenuates inflammatory response to palmitate plus LPS. (A–E) Primary hepatocytes transcript abundance of (A) Il1b , (B) Ccl2 , (C) Tnfa , and (D) Tgfb after 12hr treatment with 300 μM palmitate, LPS (0.01, 0.1, 1.0 ng/mL), and UK5099 (5 μM) or vehicle control. (Hepatocytes were pooled from three mice in technical triplicate). (Data are presented as mean ± SEM; n = 3, *p < 0.05, **p < 0.01, ***p < 0.001).
    Figure Legend Snippet: MPC inhibition attenuates inflammatory response to palmitate plus LPS. (A–E) Primary hepatocytes transcript abundance of (A) Il1b , (B) Ccl2 , (C) Tnfa , and (D) Tgfb after 12hr treatment with 300 μM palmitate, LPS (0.01, 0.1, 1.0 ng/mL), and UK5099 (5 μM) or vehicle control. (Hepatocytes were pooled from three mice in technical triplicate). (Data are presented as mean ± SEM; n = 3, *p < 0.05, **p < 0.01, ***p < 0.001).

    Techniques Used: Inhibition, Control



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    selective mpc inhibitor uk5099  (Tocris)
    95
    Tocris selective mpc inhibitor uk5099
    MPC inhibition attenuates inflammatory response to palmitate plus LPS. (A–E) Primary hepatocytes transcript abundance of (A) Il1b , (B) Ccl2 , (C) Tnfa , and (D) Tgfb after 12hr treatment with 300 μM palmitate, LPS (0.01, 0.1, 1.0 ng/mL), and <t>UK5099</t> (5 μM) or vehicle control. (Hepatocytes were pooled from three mice in technical triplicate). (Data are presented as mean ± SEM; n = 3, *p < 0.05, **p < 0.01, ***p < 0.001).
    Selective Mpc Inhibitor Uk5099, supplied by Tocris, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/selective mpc inhibitor uk5099/product/Tocris
    Average 95 stars, based on 1 article reviews
    selective mpc inhibitor uk5099 - by Bioz Stars, 2026-06
    95/100 stars
    		  Buy from Supplier

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    MPC inhibition attenuates inflammatory response to palmitate plus LPS. (A–E) Primary hepatocytes transcript abundance of (A) Il1b , (B) Ccl2 , (C) Tnfa , and (D) Tgfb after 12hr treatment with 300 μM palmitate, LPS (0.01, 0.1, 1.0 ng/mL), and UK5099 (5 μM) or vehicle control. (Hepatocytes were pooled from three mice in technical triplicate). (Data are presented as mean ± SEM; n = 3, *p < 0.05, **p < 0.01, ***p < 0.001).

    Journal: Molecular Metabolism

    Article Title: The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity

    doi: 10.1016/j.molmet.2017.09.002

    Figure Lengend Snippet: MPC inhibition attenuates inflammatory response to palmitate plus LPS. (A–E) Primary hepatocytes transcript abundance of (A) Il1b , (B) Ccl2 , (C) Tnfa , and (D) Tgfb after 12hr treatment with 300 μM palmitate, LPS (0.01, 0.1, 1.0 ng/mL), and UK5099 (5 μM) or vehicle control. (Hepatocytes were pooled from three mice in technical triplicate). (Data are presented as mean ± SEM; n = 3, *p < 0.05, **p < 0.01, ***p < 0.001).

    Article Snippet: The following day, hepatocytes were treated with 300 μM palmitate conjugated to BSA, lipopolysaccharides (LPS) from Escherichia coli O111:B4 (Sigma, L2630), and 5 μM selective MPC inhibitor UK5099 (Tocris, #4186) in DMSO (<0.01% v/v final) or appropriate vehicle controls for 12 h. Following treatment, cells were washed twice with ice-cold PBS, lysed in TRIzol (ThermoFisher/Ambion), and snap frozen in liquid nitrogen for later processing.

    Techniques: Inhibition, Control